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About
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About
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We are looking for a highly motivated and experienced Principal Scientist to lead efforts to identify and characterize translational biomarkers for our drug discovery programs. The ideal candidate will have extensive knowledge of preclinical and clinical biomarkers for Alzheimer’s, Parkinson’s or other neurodegenerative diseases. This is a full-time, on-site position requiring physical presence in our state-of-the-art facilities to conduct hands-on research and collaborate directly with cross-functional teams.
Full-Time
On Premise
New Haven, CT
Laboratory Operations
Bexorg Inc. is a translational neuroscience company developing a platform that preserves the cellular and molecular integrity of donated human brain tissue to accelerate therapeutic discovery for diseases such as Alzheimer disease and Parkinson disease. We are launching an initiative to capture the 3D structural, molecular, and omics profiles of these tissues at scale using a high-throughput robotics platform for human brain slices.
The Director of Bioengineering will be a visionary and hands-on leader responsible for building and executing a High-Throughput Brain Slice Platform: a massive fan-out drug screening program that generates up to 1,000 viable brain slices per perfused brain. These slices are incubated for up to 1 month, maintained by custom automated fluidics, and analyzed via imaging phenomics and multiscale omics to evaluate therapeutic perturbations.
Crucially, this role demands an engineering mindset obsessed with continuous iteration.
The baseline viability and fidelity of these brain slices are just the starting point. You will be expected to relentlessly optimize the platform, designing tight feedback loops that progressively enhance slice quality, longevity, and biological fidelity, ultimately maximizing their informational value for downstream therapeutic discovery.
Full-time
On Premise
New Haven, CT
Technology